Ultrasound Images and Postnatal Clinical Outcomes in Primary and Secondary Abnormalities of Fetal Brain (Series of 53 Cases)

Nowadays, in publications which dedicated to ultrasound in obstetrics a format that represents series of cases with their ultrasound images and clinical features and results is actual [1,2]. It is caused by difficulties of adequate prognosis of postnatal result, though exactly this prediction is the main task of prenatal consultation given to a pregnant woman with suspicion of abnormal development of the fetus central nervous system (CNS). Such anomalies of fetal CNS as agenesis of the corpus callosum and cortical displasia, found mainly in the second half of pregnancy, after 20-26 weeks [3]. The perinatal prognosis in some forms of antenatal fetal brain lesions is definitely unfavorable. But the information about the child development prognosis with moderate development of prosencephalon disorder, as well as in isolated and associated callosal anomalies, some kinds of the posterior fossa anomalies, hydrocephalic syndrome is contradictory and indefinite [2]. Also, there are difficult issues for prediction results in focal tumor and cystic antenatal brain lesions [3]. Diagnostics of brain lesions at the antenatal stage with a target NSG research allows to find fetuses with the necessity of postnatal observation. In the last decade, a considerable number of publications are dedicated to diagnosis of secondary fetal brain damages with infection processes, or placenta disorders [4,5]. Periventricular leukomalacia (PVL) is diffuse change of the periventricular myelin density. It’s diagnosis takes a special place in perinatal neurosonography (NSG). Antenatal PVL reports are rarely published. The research results have showed that damage of the white matter of brain is the most important prenatally identifiable risk factor for cerebral paralysis development [6-9]. The objective of study is the analysis of ultrasound (US) images, clinical perinatal and long-term results in different types of primary and secondary abnormalities of the fetal brain.